Publications
MacAlpine HR, Gordan R, Powell SK, Hartemink A, and DM MacAlpine. Drosophila ORC localizes to open chromatin and marks sites of cohesin loading. 2009. Submitted
Celniker SE, Dillon LA, Gerstein MB, Gunsalus KC, Henikoff S, Karpen GH, Kellis M, Lai EC, Lieb JD, MacAlpine DM, Micklem G, Piano F, Snyder M, Stein L, White KP, Waterston RH, and modENCODE Consortium. Unlocking the secrets of the genome. 2009. Nature 18;459(7249):927-30.
Georlette D, Ahn S, MacAlpine D, Cheung E, Lewis P, Beall E, Speed T, Manak J, and Botchan M. Genomic profiling and expression studies reveal both positive and negative roles for the Drosophila Myb-MuvB/dREAM complex in proliferating cells. 2007. Genes Dev. In Press. PMID 17978103
Bell O, Wirbelauer C, Hild M, Scharf A, Schwaiger M, MacAlpine D, Zilberman F, van Leeuwen F, Bell S, Imhof A, Garza D, Peters A, Schubeler D. Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. 2007. EMBO
J. In Press.
Park E, MacAlpine DM Orr-Weaver T, an Drosophila follicle cell amplicons as models for metazoan DNA replication: A cyclinE mutant exhibits increased replication fork elongation. 2007. PNAS. PMID 17940024
Tanny RE, MacAlpine DM, Blitzblau HG, Bell SP. Genome-wide analysis of re-replication reveals inhibitory controls that target multiple stages of replication initiation. Mol Biol Cell. 2006 May;17(5):2415-23. PMID: 16525018
MacAlpine DM, Bell SP. A genomic view of eukaryotic DNA replication. Chromosome Res. 2005;13(3):309-26. Review. PMID: 15868424
Jeon Y, Bekiranov S, Karnani N, Kapranov P, Ghosh S, MacAlpine D, Lee C, Hwang DS, Gingeras TR, Dutta A. Temporal profile of replication of human chromosomes. Proc Natl Acad Sci U S A. 2005 May 3;102(18):6419-24. PMID: 15845769
MacAlpine DM, Rodriguez HK, Bell SP. Coordination of replication and transcription along a Drosophila chromosome. Genes Dev. 2004 Dec 15;18(24):3094-105. PMID: 15601823
Schubeler D, MacAlpine DM, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwen F, Gottschling DE, O'Neill LP, Turner BM, Delrow J, Bell SP, Groudine M. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev. 2004 Jun 1;18(11):1263-71. PMID: 15175259
Claycomb JM, MacAlpine DM, Evans JG, Bell SP, Orr-Weaver TL. Visualization of replication initiation and elongation in Drosophila. J Cell Biol. 2002 Oct 28;159(2):225-36. PMID: 12403810
MacAlpine DM, Kolesar J, Okamoto K, Butow RA, Perlman PS. Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA. EMBO J. 2001 Apr 2;20(7):1807-17. PMID: 11285243
MacAlpine DM, Perlman PS, Butow RA. The numbers of individual mitochondrial DNA molecules and mitochondrial DNA nucleoids in yeast are co-regulated by the general amino acid control pathway. EMBO J. 2000 Feb 15;19(4):767-75. PMID: 10675346